We repeat: everyone has their own unique DNA, which can influence your response to vitamin D and other essential micronutrients — which in turn means you may need extra help making sure you achieve (and maintain) proper nutrition levels. So if you know you have a genetic risk for vitamin D deficiency, you can take targeted measures to proactively bridge the gap. (We believe supplementation is the most effective way to do this.*)
Regardless of your genes, the vitamin D gap is very real. More than 93% of the US population fails to consume only 400 IU of vitamin D from our daily diet, meanwhile, more than 40% of American adults meet the clinical criteria for vitamin D deficiency.
For single nucleotide polymorphisms (SNPs) that affect vitamin D status, the researchers identified a few key players. Are you ready for some modern science? First, the levels of vitamin D in the blood [serum 25(OH)D] It can be affected by the gene rs2282679, which affects the vitamin D-binding protein (VDBP). If your VDBP levels are higher, more than 25(OH)D will be bound to it and you will be less available to do its job. Thus, you may need to increase your vitamin D intake to make up for this abnormality.
“Two other polymorphisms related to 25-hydroxylase (rs10751657, CYP2R1) and 1α-hydroxylase (rs10877012, CYP27B1) have been identified,” says mbg Director of Scientific Affairs Ashley Jordan Ferreira, PhD, RDN, regarding genetic diversity. which convert vitamin D into its circulating form and its active hormonal form, respectively. Then FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236) are vitamin D receptor (VDR)-binding polymorphisms and thus the ability of vitamin D to bind and perform its many crucial functions in the body. “*